The current research focus is on the modulators of cytokine signaling (SOCS) action to control inflammation and tumor progression using in vitro and in vivo model systems
Education
(PhD) 1985 Temple University, Biochemistry
Experience
1994-present Professor, Dept. of Biological Science, Sungkyunkwan University
2005-2006 Visiting Professor, University of Washington
1989 - 1994 Senior Researcher, KIST Genetic Engineering Center
1985 - 1988 Research Associate, Harvard Medical School
2008-2015 Board member, Trustee, Korea Association of Immunologists
2005-2009 Vice president, The Association of Korean Woman Scientists and Engineers
2001-2015 Board member, Auditor , Women’s Bioscience Forum
Journal Articles
(2022)
SOCS3 Attenuates DexamethasoneInduced M2 Polarization by DownRegulation of GILZ via ROS- and p38
MAPK-Dependent Pathways.
IMMUNE NETWORK.
22,
4
(2022)
SOCS1 counteracts ROS-mediated survival signals and
promotes apoptosis by modulating cell cycle to increase
radiosensitivity of colorectal cancer cells.
BMB REPORTS.
55,
4
(2020)
Anti-inflammatory mechanisms of suppressors of cytokine signaling target ROS via NRF-2/thioredoxin induction and inflammasome activation in macrophages.
BMB REPORTS.
53,
12
(2020)
SOCS1 represses fractionated ionizing radiation-induced emt signaling pathways through the counter-regulation of ROS-scavenging and ROS-generating systems.
Cellular Physiology and Biochemistry.
54,
5
(2016)
Mechanism of suppressors of cytokine signaling 1 inhibition of epithelial-mesenchymal transition signaling through ROS regulation in colon cancer cells: suppression of Src leading to thioredoxin up-regulation.
ONCOTARGET.
7,
38
(2015)
Systemic PEGylated TRAIL treatment ameliorates liver cirrhosis in rats by eliminating activated hepatic stellate cells.
HEPATOLOGY.
63,
(2014)
Role of Promyelocytic Leukemia Zinc Finger in Cell Proliferation and Cyclin-dependent Kinase Inhibitor 1A Gene Repression.
JOURNAL OF BIOLOGICAL CHEMISTRY.
289,
77
(2012)
ANT2 suppression by shRNA may be able to exert anticancer effects in HCC further by restoring SOCS1 expression.
INTERNATIONAL JOURNAL OF ONCOLOGY.
42,
1
(2012)
Suppressors of Cytokine Signaling Promote Fas-Induced Apoptosis through Downregulation of NF-kappa B and Mitochondrial Bfl-1 in Leukemic T Cells.
JOURNAL OF IMMUNOLOGY.
189,
2
(2011)
The proto-oncogene KR-POK represses transcriptional activation of CDKN1A by MIZ-1 through competitive binding.
ONCOGENE.
1,
1
(2011)
Counter-regulation mechanism of IL-4 and IFN-alpha signal transduction through cytosolic retention of pY-STAT6:pY-STAT2:p48 complex.
EUROPEAN JOURNAL OF IMMUNOLOGY.
41,
1
(2009)
A novel POK transcription factor ZBTB5 represses transcription of p21CIP gene.
JOURNAL OF BIOLOGICAL CHEMISTRY.
284,
30
(2009)
SOCS1 protects protein tyrosine phosphatases via thioredoxin upregulation and atteuates Jaks to suppress ROS-mediated apoptosis.
ONCOGENE.
28,
35
(2009)
Eukaryotic translation initiator protein 1A isoform, CCS-3, enhances the transcriptional repression of p21CIP1 by proto-oncogene FBI-1 (Pokemon/ZBTB7A).
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY.
23,
1
(2008)
Identification of human thioredoxin as a novel IFN-gamma induced factor: Mechanism of induction and its role in cytokine production.
BMC IMMUNOLOGY.
9,
1
(2008)
Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty acid synthase gene (FASN)..
JOURNAL OF BIOLOGICAL CHEMISTRY.
283,
43
(2008)
Protooncogene FBI-1 represses transcription of tumor suppressor Rb gene by binding competition with Sp1 and recruitment of corepressors.
JOURNAL OF BIOLOGICAL CHEMISTRY.
(2008)
Induction of IFN-r gene expression by thioredoxin:positive feed-back regulation of Th1 response by thioredoxin and IFN-r.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY.
21,
(2007)
Surfactin from Bacillus Subtilis displays anti-proliferative effects via apoptosis induction, cell cycle arrest, and survival signaling suppression.
FEBS LETTERS.
581,
(2007)
Ras/MAPK pathway positively regulates Jak1/STAT6 activity and IL-4 gene expression in T Cells.
MOLECULAR IMMUNOLOGY.
44,
Publications
(2005)
The Tangled Field- 옥수수 밭의 맥클린토크.
전파과학사.
Co-author
(2002)
생명과학 의 이해.
교학사.
Co-author
Honors / Awards
Sigma-Xi Award, 1982, USA
Russell Conwell Fellowship, 1985-1988, USA
Dongcheon Science Award, 2002, KSBMB
Conference Paper
(2022)
Regulation of M1 vs M2 differentiation by SOCS1 and SOCS3 : Role of GILZ.
2022 KAI International Conference.
KOREA, REPUBLIC OF
(2022)
Role of glucocorticoid-induced leucine zipper during type II macrophage differentiation induced by dexamethasone and IL-4.
EB2022.
UNITED STATES
(2021)
Potential role of suppressors of cytokine signaling (SOCS) in M1 vs M2 macrophage function during colitis-associated cancer development in mice.
KALAS 2020 동계학술대회.
KOREA, REPUBLIC OF
(2021)
Suppressors of signaling protein 3 inhibits glucocorticoid-induced M2 polarization of monocytic cells by attenuation of p38 and GILZ-mediated anti-inflammatory cytokine induction.
Experimental Biology 2021.
UNITED STATES
(2020)
Mechanism of SOCS1 action in the promotion of glucocorticoid-induced M2 polarization.
KSBMB International Conference 2020.
KOREA, REPUBLIC OF
(2019)
Inhibition of FIR-induced EMT signal by SOCS1 through ROS regulation.
2019 ASCB / EMBO Meeting.
UNITED STATES
(2019)
Contrasting roles of SOCS1 vs SOCS3 during M2 polarization induced by dexamethasone.
KAI-2019 Fall Conference.
KOREA, REPUBLIC OF
(2019)
Roleof M1 and M2 macrophages in the control of inflammatory bowel diseases: Development of distinct colitis models to investigate the phenotypic conversion by SOCS isoforms.
KALAS International Symposium.
KOREA, REPUBLIC OF
(2019)
Regulatory roles of suppressors of cytokine signaling 1 during type I vs type II macrophage polarization and phenotype determination.
2019 Annual Meetings of American Association of Immunologists.
UNITED STATES
(2018)
Development of Inflammatory Bowel Disease Models
to Study Regulatory Effects of SOCS on M1 and M2 Phenotypic Conversion.
2018 Conference of Korean Association of Immunologists.
KOREA, REPUBLIC OF
(2018)
Role of SOCS in Redox Regulation During Type 1 and Type 2 Macrophage Polarization
and Phenotypic Conversion.
2018 Fall KAI Conference.
KOREA, REPUBLIC OF
(2018)
Differential effects of M1 and M2 macrophage-derived factors on tumor cell growth and EMT response under oxidative stress.
2018 IUBMB/KSBMB International Conference.
KOREA, REPUBLIC OF
(2018)
Regulation of dexamethasone-induced alternative macrophage differentiation signaling
by SOCS isoforms.
2018 IUBMB/KSBMB International Conference.
KOREA, REPUBLIC OF
(2017)
Tumor-immune cell interaction under ionizing irradiation regulates tumor growth and M1/M2 macrophage differentiation.
대한 면역학회 2017 추계 학술대회.
KOREA, REPUBLIC OF
(2017)
Role of ROS signal regulation by SOCS1 and SOCS3 during Th17 and Treg Differentiation.
대한 면역학회 2017 추계 학술대회.
KOREA, REPUBLIC OF
(2017)
Mechanism of FIR-induced EMT inhibition by SOCS1 through the regulation of ROS/Trx1 axis.
2017 International conference of KSMCB.
KOREA, REPUBLIC OF
(2017)
SOCS1 increases radiosensitivity of colon cancer cells by inhibition of ROS-mediated survival and EMT signal induced by ionizing radiation.
KSBMB International Conference 2017.
KOREA, REPUBLIC OF
(2017)
SOCS1 and SOCS3 inhibit ROS-mediated LPS signaling for inflammation in macrophagic cells through regulation of different anti-oxidant factors.
KSBMB International conference 2017.
KOREA, REPUBLIC OF
(2017)
Targeting Redox-regulation of TCR Signal by Suppressors of Cytokine Signaling during T cell Activation and Differentiation.
2017년 대한면역학회 춘계학술대회.
KOREA, REPUBLIC OF
(2016)
Modulation of M1 and M2 macrophage differentiation by ionizing radiation and tumor-derived factors.
대한면역학회 2016 학술대회: KAI-IBS Joint Conference.
KOREA, REPUBLIC OF
